“Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. It is also used to treat severe psoriasis and rheumatoid arthritis.

Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.

Methotrexate can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Methotrexate can cause serious or life-threatening side effects on your liver, lungs, or kidneys. Tell your doctor if you have upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), dry cough, shortness of breath, blood in your urine, or little or no urinating.”

Are you freaked out yet? Because I am. I write this from Seattle area; I am here to wrap up personal and medical appointments before heading to Oklahoma for the RVing women’s convention. First stop: both GI docs.

As my symptoms are still present, my therapy has now been augmented with methotrexate, which I inject once weekly. Setting aside for a moment the sheer terror of sticking myself with a needle (I never got used to it for the short time that I took Humira, and Humira came in a spring-loaded pen), I was terribly nauseated for a few days after the first injection – a common side effect. And then there is the potential for hair loss. Oh joy.

If methotrexate in conjunction with an Entyvio infusion every two months proves ineffective, my physician suggests that we attempt to get insurance approval for once a month infusions. That could prove a bit tricky, as the research data is not in. As you may recall, Entyvio was approved by the FDA only last May.

My doctor also raised concerns about getting infusions on the road. My insurance will cover only certain infusion centers, and then those centers must accept his orders. Or, I must find a local physician who is willing to write orders.

Oh, well. Full steam ahead. As the old song goes, “The difficult I’ll do right now; the impossible will take a little while.”